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Psalmotoxin 1/ PcTx1
簡(jiǎn)要描述：Smartox Biotechnology是*一家專門生產(chǎn)動(dòng)物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
產(chǎn)品型號(hào)：13PCT001- 廠商性質(zhì)：代理商
- 更新時(shí)間：2024-10-30
- 訪 問(wèn) 量：1875
產(chǎn)品介紹
Psalmotoxin 1 /PcTx1
ASIC1a selective blocker(酸敏感通道ASIC1a選擇性阻斷劑)
Psalmotoxin-1 (PcTx1, Pi-theraphotoxin-Pc1a) has been isolated from the venom of the Spider Psalmopoeus cambridgei (Trinidad chevron tarantula). PcTx1 is known to block potently (IC50 = 1 nM) and selectively the H+-gated sodium channel ASIC1a (acid-sensitive ion channel 1a). The blockage is rapid and reversible. PcTx1 can distinguish between the two ASIC1 splice variants ASIC1a and ASIC1b. PcTx1 loses its capacity to block ASIC1a as soon as this subunit is associated with another member of the family (ASIC2a or ASIC3). PcTx1 demonstrates an analgesic effect in acute and neuropathic pain models.
PcTx1技術(shù)資料
氨基酸序列：Glu-Asp-Cys3-Ile-Pro-Lys-Trp-Lys-Gly-Cys10-Val-Asn-Arg-His-Gly-Asp-Cys17-Cys18-Glu-Gly-Leu-Glu-Cys23-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys33-Val-Pro-Lys-Thr-Pro-Lys-Thr
二硫鍵：Cys3-Cys18, Cys10-Cys23 and Cys17-Cys33
長(zhǎng)度 (aa)： 40
分子式： C200H312N62O57S 6
分子量： 4690.82 Da
外觀：White lyophilized solid
可溶性： water and saline buffer
CAS 號(hào)：not available
來(lái)源：Synthetic
純度： > 98%
產(chǎn)品信息
13PCT001-00100 | PcTx1 | 0.1mg |
13PCT001-00500 | PcTx1 | 0.5mg |
13PCT001-01000 | PcTx1 | 1mg |
