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Guangxitoxin 1E（GxTx-1E）
簡(jiǎn)要描述：Smartox Biotechnology是*一家專門(mén)生產(chǎn)動(dòng)物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
產(chǎn)品型號(hào)：11GUA002- 廠商性質(zhì)：代理商
- 更新時(shí)間：2024-10-29
- 訪 問(wèn) 量：1724
產(chǎn)品介紹
Guangxitoxin 1E
Selective blocker of Kv2.1 and Kv2.2(鉀離子通道Kv2.1 和 Kv2.2選擇性阻斷劑)
Guangxitoxin-1E (GxTx-1E) was isolated from the venom of Chilobrachys jingzhao (Chinese earth tiger tarantula).Guangxitoxin-1E was shown to block Kv2.1/KCNB1, Kv2.2/KCNB2 and Kv4.3/KCND3 channels without significant effect on Kv1.2/KCNA2, Kv1.3/KCNA3, Kv1.5/KCNA5, Kv3.2/KCNC2, Cav1.2/CACNA1C, Cav2.2/CACNA1B, Nav1.5/SCN5A, Nav1.7/SCN9A or Nav1.8/SCN10A channels. Guangxitoxin-1E inhibits Kv2.1 with an IC50 value of 1 nM and Kv2.2 with an IC50 value of 3 nM. Block of Kv4.3 occurs at 10-20 fold higher concentrations. Guangxitoxin-1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials. In pancreatic beta-cells, Guangxitoxin-1E enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations.
治療領(lǐng)域：Diabetes type 2（II型糖尿病）
Guangxitoxin-1E 技術(shù)資料
氨基酸序列：
Glu-Gly-Glu-Cys4-Gly-Gly-Phe-Trp-Trp-Lys-Cys11-Gly-Ser-Gly-Lys-Pro-Ala-Cys18-Cys19-Pro-Lys-Tyr-Val-Cys24-Ser-Pro-Lys-Trp-Gly-Leu-Cys31-Asn-Phe-Pro-Met-Pro-OH
二硫鍵（Presumed disulfide bridge pattern）： Cys4-Cys19, Cys11-Cys24 and Cys18-Cys31
長(zhǎng)度 (aa)：36
分子式：C178H248N44O45S7
分子量：3948.70 Da
外觀：White lyophilized solid
可溶性：water and saline buffer
CAS 號(hào)：not available
來(lái)源：Synthetic
純度： > 95%
產(chǎn)品信息
11GUA002-00050 | GxTx-1E | 0.05mg |
11GUA002-50050 | GxTx-1E | 5 x 0.05mg |
1GUA002-00100 | GxTx-1E | 0.1mg |
11GUA002-00500 | GxTx-1E | 0.5mg |
